Abstract | BACKGROUND: We evaluated the clinical performance of a novel cardiac troponin I (cTnI) assay specifically designed to improve the very early risk stratification in acute coronary syndromes. SUBJECTS AND METHODS: Serum and plasma samples (taken 0, 6-12 h and 24 h after admission) from 531 patients with suspected acute coronary syndrome were studied using a novel investigational cTnI assay, reference cTnI assay and myoglobin. The lowest cTnI concentration giving a total assay imprecision of 10% was used as the positive myocardial infarction (MI) cut-off value. RESULTS: At the time of admission, the investigational assay was positive in 27.9% of the patients, the reference cTnI assay was positive in only 17.5% (P < 0.001) and myoglobin in 24.1% (P = 0.067). Receiver operating characteristic (ROC) curve analysis for the detection of myocardial injury on admission gave area-under-curve (AUC) values of 0.937, 0.775 and 0.762, respectively (P < 0.001). Of those MI patients who presented within 3 h of symptom onset, 50.0% were identified by the investigational assay at the time of presentation, compared with 44.2% by myoglobin (P = 0.791) but only 11.5% by the reference assay (P < 0.001). CONCLUSIONS: The novel cTnI assay considerably improves the performance of cTnI as an early rule-in biomarker for MI.
|
Authors | T Ilva, S Eriksson, J Lund, P Porela, H Mustonen, K Pettersson, K Pulkki, L-M Voipio-Pulkki |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 35
Issue 2
Pg. 112-6
(Feb 2005)
ISSN: 0014-2972 [Print] England |
PMID | 15667582
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Aged
- Area Under Curve
- Early Diagnosis
- Female
- Humans
- Immunoassay
(methods, standards)
- Male
- Myocardial Infarction
(diagnosis)
- Risk Assessment
- Sensitivity and Specificity
- Troponin I
(blood)
|