Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid.

Abstract

The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL, P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.

• Authors: Birger Trollfors, John Taranger, Teresa Lagergård, Valter Sundh
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 24 Issue 1 Pg. 85-6 (Jan 2005) ISSN: 0891-3668 [Print] United States
• PMID: 15665717 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antibodies, Bacterial
• Diphtheria Toxoid
• Diphtheria-Tetanus Vaccine
• Immunoglobulin G
• Tetanus Toxoid
• Toxoids
• Vaccines, Acellular
• Vaccines, Combined
• pertussis toxoid

Topics

• Animals
• Antibodies, Bacterial (blood)
• Child, Preschool
• Chlorocebus aethiops
• Diphtheria (prevention & control)
• Diphtheria Toxoid (administration & dosage, immunology)
• Diphtheria-Tetanus Vaccine (administration & dosage, immunology)
• Double-Blind Method
• Drug Interactions
• Humans
• Immunoglobulin G (blood)
• Infant
• Tetanus (prevention & control)
• Tetanus Toxoid (administration & dosage, immunology)
• Toxoids (administration & dosage, immunology)
• Vaccines, Acellular (administration & dosage, immunology)
• Vaccines, Combined (administration & dosage, immunology)
• Vero Cells
• Whooping Cough (prevention & control)