[Gene expression of type X collagen in the intervertebral disc of idiopathic scoliosis patients].

Abstract

OBJECTIVE:

To observe the characteristics of gene expression of type X collagen in the cartilage of end-plate and the fibrous annulus in the intervertebral disc of idiopathic scoliosis (IS) patients.

METHOD:

Investigating the expression of type X collagen in the peak disc and the lower end disc of 21 IS patients, the peak disc of 16 congenital scoliosis (CS) and the lumbar disc of 3 normal people (according with the principle of medical ethnics) by reverse transcript polymerase chain reaction.

RESULTS:

The expression of type X collagen in the concave side of IS peak disc was higher than the convex side (P < 0.05). There was no significant difference of gene expression of type X collagen between the convex side and the concave side of the lower end disc (P > 0.05). The gene expression of type X collagen in the IS peak disc was higher than those of lower end disc (P < 0.05). For the CS peak discs, the expression of type X collagen of the concave side was higher than the convex side (P < 0.05).

CONCLUSION:

The expression of type X collagen of the IS peak disc increases, and the expression of type X collagen of the concave side is higher than the convex side. These changes may be secondary.

• Authors: Qi Lin, Zhi-Hong Wu, Yong Liu, Yi-Peng Wang, Xi-Sheng Weng, Jin Lin, Ye Tian, Jian-Xiong Shen, Hong Zhao, Jian-Guo Zhang, Gui-Xing Qiu
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 26 Issue 6 Pg. 696-9 (Dec 2004) ISSN: 1000-503X [Print] China
• PMID: 15663235 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type X

Topics

• Adolescent
• Child
• Collagen Type X (genetics, metabolism)
• Female
• Gene Expression
• Humans
• Intervertebral Disc (metabolism)
• Male
• Scoliosis (genetics, metabolism)