HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Analysis of hyperpigmentation and hypopigmentation after Er:YAG laser skin resurfacing.

AbstractBACKGROUND AND OBJECTIVES:
Pigmentary disorders--such as hyperpigmentation and hypopigmentation, are devastating complications of erbium:yttrium-aluminum-garnet (Er:YAG) laser resurfacing. This study was undertaken to assess the clinical and histopathologic features of hyperpigmentation and hypopigmentation following Er:YAG laser resurfacing, especially in darker skin.
STUDY DESIGN/MATERIALS AND METHODS:
One hundred and ninety patients (skin phototypes III and above), treated with Er:YAG lasers--short-pulsed and modulated (variable-pulsed and dual-mode) Er:YAG lasers--for skin resurfacing were recruited. The clinical features of hyperpigmentation and hypopigmentation were evaluated retrospectively using medical charts and serial photographs. For histopathologic examinations, skin biopsies were performed in three patients at hyperpigmentation sites and in four patients at hypopigmentation sites.
RESULTS:
Hyperpigmentation was observed in 38.4% of the patients. Mean onset and duration were 3.5 and 7.2 weeks, and then it has faded away within 16 weeks in 93.2% of cases. Hypopigmentation was observed in 13.7% of the patients; its mean onset was 2 months after treatment, and it faded within 1 year in 85% of cases. The incidences and mean durations of these side effects were more intense and longer in patients treated with short-pulsed, variable-pulsed, and dual-mode Er:YAG lasers, in increasing order. In terms of histopathologic examinations, melanin amounts in the epidermal basal layer were observed to vary.
CONCLUSIONS:
Hyperpigmentation and hypopigmentation are frequent complications of Er:YAG laser resurfacing. Long pulse duration-induced thermal damage seems to be the most important factor in terms of the induction of pigmentary disorders.
AuthorsYong Ju Kim, Ho-Sup Lee, Sang-Wook Son, Soo-Nam Kim, Young-Chul Kye
JournalLasers in surgery and medicine (Lasers Surg Med) Vol. 36 Issue 1 Pg. 47-51 (Jan 2005) ISSN: 0196-8092 [Print] United States
PMID15662626 (Publication Type: Journal Article)
Chemical References
  • Hydroquinones
  • Radiation-Protective Agents
  • hydroquinone
Topics
  • Adult
  • Cicatrix (radiotherapy)
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroquinones (therapeutic use)
  • Hyperpigmentation (drug therapy, etiology, pathology)
  • Hypopigmentation (etiology, pathology)
  • Lasers (adverse effects)
  • Male
  • Middle Aged
  • Radiation-Protective Agents (therapeutic use)
  • Remission, Spontaneous
  • Retrospective Studies
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: