Abstract | BACKGROUND: OBJECTIVE: METHODS: Blood samples and cervical swabs were obtained from 36 patients and 79 healthy controls; additional cervical biopsies were obtained from all the patients. HPV DNA was detected by PCR and HLA-DQB1 genotyping was performed using a PCR-SSP protocol. RESULTS.: A positive association with cervical cancer was observed for HLA-DQB1*0201-0202 and *0402 alleles, however after Bonferroni correction only HLA-DQB1*0402 remained statistically significant (P value = 0.004, RR = 5.067). CONCLUSION:
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Authors | Dat D Dao, Carlos H Sierra-Torres, Sonia C Robazetti, Miriam Naranjo de Gomez, Rolf König, Carolina Lema, L James Lester, William W Au, Stephen K Tyring |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 96
Issue 2
Pg. 349-54
(Feb 2005)
ISSN: 0090-8258 [Print] United States |
PMID | 15661220
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
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Topics |
- Adult
- Aged
- Alleles
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
(blood, genetics)
- HLA-DQ beta-Chains
- Humans
- Middle Aged
- Papillomaviridae
- Papillomavirus Infections
(complications)
- Uterine Cervical Neoplasms
(genetics, immunology, virology)
- Venezuela
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