Rotavirus vaccines: an update.

Abstract

PURPOSE OF REVIEW:

Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and has a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease.

RECENT FINDINGS:

Rotavirus disease prevention efforts suffered a great setback in 1999 with the withdrawal of the RRV-TV vaccine less than a year after its introduction. Several new rotavirus vaccine candidates have now been developed and are undergoing clinical trials.

SUMMARY:

New safe and effective rotavirus vaccines offer the best hope of reducing the toll of acute rotavirus gastroenteritis in both developed and developing countries.

• Authors: Penelope H Dennehy
• Journal: Current opinion in pediatrics (Curr Opin Pediatr) Vol. 17 Issue 1 Pg. 88-92 (Feb 2005) ISSN: 1040-8703 [Print] United States
• PMID: 15659970 (Publication Type: Journal Article, Review)

Chemical References

• Rotavirus Vaccines
• rhesus rotavirus vaccine

Topics

• Child, Preschool
• Diarrhea (prevention & control)
• Humans
• Infant
• Intussusception (chemically induced)
• Rotavirus Infections (prevention & control)
• Rotavirus Vaccines (adverse effects, genetics, therapeutic use)