Abstract |
CD4 T helper 2 (Th2) cells, with the characteristic interleukin (IL)-4, IL-5, and IL-13 cytokine secretion profile, play an important role in the initiation and perpetuation of allergic airways disease. It is clear from recent studies that CD4+ T cells with distinct cytokine-producing abilities have regulatory functions that limit allergic inflammation. Studies of allergic airway inflammation in mice have identified different types of T regulatory cells (Tregs) that control the disease phenotype. The cytokines associated with the Treg phenotype in mice include both soluble and cell membrane-bound transforming growth factor ( TGF)-beta and IL-10. Both contact-dependent mechanisms involving membrane-bound TGF-beta and contact-independent mechanisms involving soluble TGF-beta and IL-10 have been invoked to describe the function of these Tregs. In humans, studies of milk allergy show an association between circulating CD4+CD25+ Tregs and tolerance to the causative allergen, beta-lactoglobulin. The identification of Tregs as suppressors of allergic disease may promote the development of new therapeutic strategies.
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Authors | Marina Ostroukhova, Anuradha Ray |
Journal | Current allergy and asthma reports
(Curr Allergy Asthma Rep)
Vol. 5
Issue 1
Pg. 35-41
(Jan 2005)
ISSN: 1529-7322 [Print] United States |
PMID | 15659261
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Allergens
- CD4 Antigens
- DNA-Binding Proteins
- FOXP3 protein, human
- Forkhead Transcription Factors
- Foxp3 protein, mouse
- Receptors, Interleukin-2
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Topics |
- Allergens
(adverse effects)
- Animals
- Asthma
(immunology, physiopathology)
- CD4 Antigens
(immunology, physiology)
- DNA-Binding Proteins
(genetics, metabolism)
- Desensitization, Immunologic
- Disease Models, Animal
- Female
- Forkhead Transcription Factors
- Humans
- Lymphocyte Activation
- Male
- Mice
- Receptors, Interleukin-2
(immunology, physiology)
- Sensitivity and Specificity
- T-Lymphocyte Subsets
(immunology, physiology)
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