[Effects of shuangshen tongguan (SSTG) on TNF-alpha, ICAM-1 during myocardial ischemia-reperfusion injury].

Abstract

OBJECTIVE:

To observe the effects of SSTG on infarction size and tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion molecular-1 (ICAM-1) levels in serum during reperfusion injury of acute myocardial ischemia.

METHOD:

Anterior descending branch of coronary artery was ligated and released to create myocardial ischemia-reperfusion injury. The size and weight of infarction area and the contents of TNF-alpha, IGAM-1 in serum were assayed by N-BT staining and ELISA respectively.

RESULT:

The size and weight of infarct area and the contents of TNF-alpha, ICAM-1 in serum were significantly increased compared with the normal group and were obviously decreased after being treated with SSIG.

CONCLUSION:

Ischemia-reperfusion stimulated the secretion of TNF-alpha and ICAM-1, which play an important role in ischemia-reperfusion injury. SSTG might protect myocardium from ischemia-reperfusion injury by suppressing over-secretion of TNF-alpha and ICAM-1 and reducing the size and weight of infarction area.

• Authors: Xiao Han, Jian-xun Liu, Xiao-bin Ma, Yang-hui Wang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 29 Issue 11 Pg. 1073-5 (Nov 2004) ISSN: 1001-5302 [Print] China
• PMID: 15656142 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• Tumor Necrosis Factor-alpha
• Intercellular Adhesion Molecule-1

Topics

• Animals
• Drug Combinations
• Drugs, Chinese Herbal (pharmacology)
• Intercellular Adhesion Molecule-1 (blood)
• Myocardial Infarction (blood, pathology)
• Myocardial Reperfusion Injury (blood, pathology)
• Myocardium (pathology)
• Panax (chemistry)
• Plants, Medicinal (chemistry)
• Rats
• Rats, Sprague-Dawley
• Salvia miltiorrhiza (chemistry)
• Tumor Necrosis Factor-alpha (metabolism)