Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.

Abstract

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2',4'-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

• Authors: Ya-ming Xu, Randall K Johnson, Sidney M Hecht
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 13 Issue 3 Pg. 657-9 (Feb 01 2005) ISSN: 0968-0896 [Print] England
• PMID: 15653332 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Ethers
• Polybrominated Biphenyls
• Receptor, TIE-2

Topics

• Animals
• Ethers (chemistry)
• Magnetic Resonance Spectroscopy
• Polybrominated Biphenyls (isolation & purification, pharmacology)
• Porifera (chemistry)
• Receptor, TIE-2 (antagonists & inhibitors)