| Abstract | We investigated the therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175-200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D3 and the other with saline for up to 4 days after the head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the level of neuronal, vascular and axonal damage. There were no significant differences between the groups after 1 or 3 days, but evaluation after 8 days revealed a significant improvement in the group treated with vitamin D3. Our data indicate that vitamin D3 has a beneficial effect in diffuse axonal injury and may be useful in the management of this condition. |
| Authors | U A Malcok, G Sengul, H H Kadioglu, I H Aydin
(Affiliation: Department of Neurosurgery, Medical School, Ataturk University, Erzurum, Turkey. umitali at atauni.edu.tr)
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| Journal | The Journal of international medical research
(J Int Med Res)
2005 Jan-Feb
Vol. 33
Issue 1
Pg. 90-5
ISSN: 0300-0605 England |
| PMID | 15651720
(Publication Type: Comparative Study, Journal Article)
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| Chemical References |
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| Topics |
- Animals
- Axons
- Cholecalciferol
(therapeutic use)
- Male
- Models, Animal
- Rats
- Rats, Sprague-Dawley
- Wounds and Injuries
(drug therapy)
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