Effectiveness of colchicine in a case of recurrent compressive rheumatoid pericarditis.

Abstract

Survival is impaired in rheumatoid pericarditis complicated by cardiac compression by either tamponade or constriction. Conventional therapy with non-steroidal anti-inflammatory agents and glucocorticoids is frequently ineffective in reversing severe cardiac impairment and/or in preventing recurrences. Colchicine, an effective and safe treatment of idiopathic and post-viral pericarditis, has not been studied in rheumatoid pericarditis. We describe the case of a 44-year-old woman with a 1-year history of rheumatoid arthritis who developed rheumatoid pericarditis complicated with tamponade. Pericardiocentesis relieved the symptoms, but pericarditis recurred at a high dose of prednisone of 70 mg/day. Colchicine at a dose of 1 mg/day prevented recurrences and had a significant sparing effect on steroids, which were reduced to 6 mg/day. This is the second case report describing the effectiveness of colchicine therapy in rheumatoid pericarditis complicated with tamponade. These cases suggest that colchicine should be considered in the treatment of rheumatoid pericarditis.

• Authors: Pascal Sève, Katia Stankovic, Christiane Broussolle
• Journal: Rheumatology international (Rheumatol Int) Vol. 25 Issue 7 Pg. 558-61 (Sep 2005) ISSN: 0172-8172 [Print] Germany
• PMID: 15645232 (Publication Type: Case Reports, Journal Article)

Chemical References

• Colchicine

Topics

• Adult
• Arthritis, Rheumatoid (complications, diagnosis)
• Biopsy, Needle
• Chest Pain (diagnosis, etiology)
• Colchicine (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Pericarditis, Constrictive (drug therapy, etiology, pathology)
• Recurrence
• Risk Assessment
• Severity of Illness Index
• Tomography, X-Ray Computed (methods)
• Treatment Outcome