Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.

Abstract

The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.

• Authors: Katrina M Miranda, Andrew S Dutton, Lisa A Ridnour, Christian A Foreman, Eleonora Ford, Nazareno Paolocci, Tatsuo Katori, Carlo G Tocchetti, Daniele Mancardi, Douglas D Thomas, Michael G Espey, K N Houk, Jon M Fukuto, David A Wink
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 127 Issue 2 Pg. 722-31 (Jan 19 2005) ISSN: 0002-7863 [Print] United States
• PMID: 15643898 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitric Oxide Donors
• Nitrites
• Oxidants
• Solutions
• oxyhyponitrite
• Oxygen

Topics

• Hydrogen-Ion Concentration
• Nitric Oxide Donors (chemistry, metabolism)
• Nitrites (chemistry, metabolism)
• Oxidants (chemistry, metabolism)
• Oxidation-Reduction
• Oxygen (chemistry)
• Quantum Theory
• Solutions
• Spectrometry, Fluorescence
• Thermodynamics