Protective effects of rutaecarpine in cardiac anaphylactic injury is mediated by CGRP.

Abstract	Previous investigations have indicated that rutaecarpine activates the vanilloid receptor to evoke calcitonin gene-related peptide (CGRP) release. CGRP has been shown to alleviate cardiac anaphylactic injury. In the present study, the effect of rutaecarpine on cardiac anaphylaxis was examined. Challenge of presensitized guinea-pig hearts with a specific antigen caused marked decreases in coronary flow (CF), left ventricular pressure (LVP) and its derivatives (+/- dp/dt(max)), an increase in heart rate, and prolongation of the P-R interval. Rutaecarpine (0.3 or 1 microM) markedly increased the content of calcitonin gene-related peptide (CGRP) in the coronary effluent and decreased the content of tumor necrosis factor-alpha (TNF-alpha) in myocardial tissues concomitantly with a significant improvement of cardiac function and alleviation of the extension of the P-R interval. Rutaecarpine at the concentration of 1 microM also inhibited the sinus tachycardia. The protective effects of rutaecarpine on cardiac anaphylaxis were abolished by CGRP (8-37), a selective CGRP receptor antagonist. These results suggest that the protective effects of rutaecarpine on cardiac anaphylactic injury are related to inhibition of TNF-alpha production by stimulation of CGRP release.
Authors	Hong-Hui Yi, Wei-Qing Rang, Pan-Yue Deng, Chang-Ping Hu, Gui-Zhen Liu, Gui-Shan Tan, Kang-Ping Xu, Yuan-Jian Li
Journal	Planta medica (Planta Med) Vol. 70 Issue 12 Pg. 1135-9 (Dec 2004) ISSN: 0032-0943 [Print] Germany
PMID	15643546 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Alkaloids Cardiotonic Agents Indole Alkaloids Quinazolines Tumor Necrosis Factor-alpha rutecarpine
Topics	Alkaloids (administration & dosage, pharmacology, therapeutic use) Anaphylaxis (physiopathology, prevention & control) Animals Blood Pressure Cardiotonic Agents (administration & dosage, pharmacology, therapeutic use) Coronary Vessels (physiopathology) Evodia Female Guinea Pigs Heart (drug effects, physiopathology) Heart Rate Indole Alkaloids Male Myocardium (metabolism) Phytotherapy Quinazolines Tumor Necrosis Factor-alpha (metabolism)

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