Antiviral effect of chinonin against herpes simplex virus.

Abstract

In order to investigate the antiviral effect of chinonin against Herpes simplex virus (HSV), the encephalitis model in mice and skin infection model in guinea pigs were established by HSV- I and HSV-II infection respectively. Acyclovir was used as the positive reference drug to evaluate the antiviral capacity of chinonin. Chinonin showed an obvious therapeutic effect on encephalitis in mice at doses of 25 and 50 mg/kg. At both dosages, chinonin demonstrated stronger protection than acyclovir (1 and 5 mg/kg) to the infected mice from death. It was also found that chinonin could treat the skin infection in guinea pigs effectively. The therapeutic effect of chinonin was similar to that of acyclovir (5 mg/kg) at 25 mg/kg but obviously better than that at 50 and 75 mg/ kg. In conclusion, chinonin is a potential candidate for the treatment against HSV.

• Authors: Jie Jiang, Sha Li, Ming Li, Jizhou Xiang
• Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 24 Issue 5 Pg. 521-4 ( 2004) ISSN: 1672-0733 [Print] China
• PMID: 15641710 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiviral Agents
• Glycosides
• Xanthenes
• Xanthones
• mangiferin
• Acyclovir

Topics

• Acyclovir (therapeutic use)
• Animals
• Antiviral Agents (pharmacology)
• Encephalitis (drug therapy, virology)
• Glycosides (pharmacology)
• Guinea Pigs
• Herpes Simplex (drug therapy)
• Herpesvirus 1, Human (drug effects)
• Herpesvirus 2, Human (drug effects)
• Mice
• Simplexvirus (drug effects)
• Skin Diseases, Infectious (drug therapy)
• Xanthenes (pharmacology)
• Xanthones