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Serum androstanediol glucuronide in women with facial hirsutism.

AbstractBACKGROUND:
Measurement of serum 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-diolG) has been proposed as a useful biochemical marker of peripheral androgen metabolism. Is 3 alpha-diol G a useful biochemical marker of peripheral androgen metabolism and does it correlate with degree of facial hirsutism?
OBJECTIVE:
Our purpose was to assess possible correlation between serum 3 alpha-diol G and degree of facial hirsutism and to compare serum 3 alpha-diol G levels with levels of other commonly measured serum androgens.
METHODS:
Twenty-three consecutive women with facial hirsutism were studied, and serum concentrations of 3 alpha-diol G, testosterone (total, free, and biologically active portions), dehydroepiandrosterone sulfate, and androstenedione were measured.
RESULTS:
There was no correlation between serum 3 alpha-diol G levels and degree of facial hirsutism. There was a correlation between levels of 3 alpha-diol G and dehydroepiandrosterone sulfate (p less than 0.01), biologically active testosterone (p = 0.01), free free testosterone (p less than 0.02), and androstenedione (p less than 0.05).
CONCLUSION:
Serum 3 alpha-diol G concentrations have no correlation with degree of facial hirsutism and do not provide additional information over the commonly measured androgens.
AuthorsK Salman, R L Spielvogel, L H Shulman, J L Miller, R E Vanderlinde, L I Rose
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 26 Issue 3 Pt 2 Pg. 411-4 (Mar 1992) ISSN: 0190-9622 [Print] United States
PMID1564146 (Publication Type: Journal Article)
Chemical References
  • Androgens
  • Biomarkers
  • Androstane-3,17-diol
  • androstane-3,17-diol glucuronide
Topics
  • Adolescent
  • Adult
  • Androgens (blood)
  • Androstane-3,17-diol (analogs & derivatives, blood)
  • Biomarkers (blood)
  • Facial Dermatoses (blood)
  • Female
  • Hirsutism (blood)
  • Humans

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