15d-PGJ2: the anti-inflammatory prostaglandin?

Abstract

15-Deoxy-Delta-12,14-prostaglandin J2 (15d-PGJ2) is the most recently discovered prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other prostaglandins in several respects. There is no specific prostaglandin synthase (PGS) leading to 15d-PGJ2 production and no specific 15d-PGJ2 receptor has been identified to date. Instead, 15d-PGJ2 has been shown to act via PGD2 receptors (DP1 and DP2) and through interaction with intracellular targets. In particular, 15d-PGJ2 is recognized as the endogenous ligand for the intranuclear receptor PPARgamma. This property is responsible for many of the 15d-PGJ2 anti-inflammatory functions. In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states.

• Authors: Jose U Scher, Michael H Pillinger
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 114 Issue 2 Pg. 100-9 (Feb 2005) ISSN: 1521-6616 [Print] United States
• PMID: 15639643 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• 15-deoxyprostaglandin J2
• NF-kappa B
• PPAR gamma
• Prostaglandin-Endoperoxide Synthases
• Prostaglandin D2

Topics

• Animals
• Autoimmune Diseases (immunology)
• Humans
• Inflammation (immunology)
• NF-kappa B (immunology)
• PPAR gamma (immunology)
• Prostaglandin D2 (analogs & derivatives, biosynthesis, immunology)
• Prostaglandin-Endoperoxide Synthases (metabolism)