Preparation of 2-pyridone-containing tricyclic alkaloid derivatives as potential inhibitors of tumor cell proliferation by regioselective intramolecular N- and C-acylation of 2-pyridone.

Abstract

A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair of structural isomers 2-aryl pyrido[2,1-a]isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno[1,2-b]-pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively.

• Authors: Shaozhong Wang, Liya Cao, Haijian Shi, Yanmei Dong, Jianwei Sun, Yuefei Hu
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 53 Issue 1 Pg. 67-71 (Jan 2005) ISSN: 0009-2363 [Print] Japan
• PMID: 15635233 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Growth Inhibitors
• Pyridones
• 2-hydroxypyridine

Topics

• Acylation (drug effects)
• Alkaloids (chemical synthesis, pharmacology)
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Proliferation (drug effects)
• Growth Inhibitors (chemical synthesis, pharmacology)
• Pyridones (chemical synthesis, pharmacology)
• Stereoisomerism