Abstract |
Five new compounds, hibicuslide A (1), hibicuslide B (2), hibicuslide C (3), hibicutaiwanin (4), hibicusin (5), and fifty-one known compounds have been isolated from the stems of Hibiscus taiwanensis. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Among them, mansonone H (19) and uncarinic acid A (30) inhibited HIV replication in H9 lymphocyte cells. The 9,9'-O-feruloyl-(-)-secoisolaricinresinol (12), myriceric acid C (29), and uncarinic acid A (30) showed cytotoxic activity against human lung carcinoma and breast carcinoma.
|
Authors | Pei-Lin Wu, Tian-Shung Wu, Cai-Xia He, Chia-Hao Su, Kuo-Hsiung Lee |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 53
Issue 1
Pg. 56-9
(Jan 2005)
ISSN: 0009-2363 [Print] Japan |
PMID | 15635230
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Cell Line, Tumor
- HIV-1
(drug effects, physiology)
- Hibiscus
- Humans
- Lymphocytes
(drug effects, virology)
- Plant Extracts
(chemistry, isolation & purification, pharmacology)
- Plant Stems
|