Abstract | BACKGROUND: METHODS: Sixty-five skeletally mature patients undergoing primary anterior cruciate ligament reconstruction were randomly assigned to one of three groups, all of which received an intra-articular injection consisting of 9.5 mL of 0.5% bupivacaine with 1:200,000 epinephrine at the completion of the procedure. In addition, the remaining 0.5 mL of the syringe was filled with one of three substances. The study group (twenty-five patients) received 5 mg of methadone, the comparison group (twenty-one patients) received 5 mg of morphine, and the control group (nineteen patients) received 0.5 mL of saline solution. All supplemental pain medications were given on an as-needed basis, recorded, and converted to morphine equivalents. Specific variables that were measured included supplemental analgesia requirements during both the inpatient period and the outpatient period (from the time of discharge to the seventh postoperative day) and pain scores. RESULTS: There was no significant difference in inpatient (p = 0.998) or outpatient (p = 0.887) supplemental analgesic requirements or pain scores between the methadone group (Group 1) and the control group (Group 3). The morphine group (Group 2) required significantly less inpatient (p = 0.014) and outpatient (p = 0.044) supplemental analgesia compared with the control group (Group 3). There were no complications. CONCLUSIONS:
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Authors | David J Stewart, Edward W Lambert, Kimberly M Stack, Joseph Pellegrini, Daniel V Unger, Raymond J Hood |
Journal | The Journal of bone and joint surgery. American volume
(J Bone Joint Surg Am)
Vol. 87
Issue 1
Pg. 140-4
(Jan 2005)
ISSN: 0021-9355 [Print] United States |
PMID | 15634825
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Morphine
- Methadone
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Topics |
- Adult
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anterior Cruciate Ligament
(surgery)
- Arthroscopy
- Female
- Humans
- Injections, Intra-Articular
- Knee Joint
- Male
- Methadone
(administration & dosage, therapeutic use)
- Morphine
(administration & dosage, therapeutic use)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
- Prospective Studies
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