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[TTF-1 expression and its diagnostic application in lung carcinomas].

AbstractOBJECTIVE:
To detect the expression of thyroid transcription factor 1 (TTF-1) and study its application in the diagnosis of lung carcinomas.
METHODS:
Of 134 specimens from lung lobectomy, 105 were primary lung carcinomas including 76 non-small cell carcinomas (NSCLCs), 28 small cell lung cancers (SCLCs) and 1 complex carcinoma (SCLC and SCC), and 29 were metastatic carcinomas. Expression of TTF-1 was detected by immunohistochemistry. The expression level of TTF-1 was graded as, +:6% to 25% of tumor cells positive, ++:26% to 50%, +++:51% to 75%, and ++++:> 76%.
RESULTS:
The positive nuclear immunoreactivity of TTF-1 was identified in 23 of 28 SCLCs (82.1%), but none in squamous cell cancer (SCC) (P < 0.001). The positive expression rate of TTF-1 in lung adenocarcinomas (ACs) was 73.8% (31/42). There was no correlation between TTF-1 expression and ACs differentiation or ACs subtypes (P > 0.05). All but one (thyroid follicular carcinoma) metastatic ACs were TTF-1-positive. Mesenchymal component and lymphoid or inflammatory cells were consistently TTF-1-negative.
CONCLUSION:
A significant difference of TTF-1 expression may assist in distinguishing SCLC from SCC, lymphoma or inflammatory lesions. Owing to its restrictive expression in lung tissue, TTF-1 might be used to differentiate primary from metastatic adenocarcinoma of the lung.
AuthorsDong-mei Lin, Shuang-mei Zou, Ning Lü, Peng Wen, Xiu-yun Liu, Zu-gen He
JournalZhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 26 Issue 10 Pg. 615-7 (Oct 2004) ISSN: 0253-3766 [Print] China
PMID15634524 (Publication Type: Journal Article)
Chemical References
  • NKX2-1 protein, human
  • Nuclear Proteins
  • Thyroid Nuclear Factor 1
  • Transcription Factors
Topics
  • Adenocarcinoma (diagnosis, metabolism)
  • Breast Neoplasms (pathology)
  • Carcinoma, Non-Small-Cell Lung (diagnosis, metabolism)
  • Colorectal Neoplasms (pathology)
  • Diagnosis, Differential
  • Humans
  • Lung Neoplasms (diagnosis, metabolism, secondary)
  • Nuclear Proteins (biosynthesis)
  • Thyroid Nuclear Factor 1
  • Transcription Factors (biosynthesis)

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