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[A preliminary report on treatment of myelodysplastic syndrome with cyclosporin a and androgen].

Abstract
The study was aimed to explore clinical result of cyclosporin A (CsA) and androgens for treatment of myelodysplastic syndrome (MDS) with refractory anemia. Four cases of MDS-RA were treated with CsA and androgens, while the changes of blood counts, bone marrow and chromosome were observed. The results showed that substantial hematological response was observed in all four patients, that their anemia improved and all transfusion-dependent patients achieved transfusion independence. In conclusion, CsA and Adr therapy was well tolerated. CsA and Adr therapy offer an alternative treatment of MDS with RA. The mechanisms of the benifical effect from this therapy remain the subject of an ongoing study.
AuthorsJing-Wen Wang, Feng Ning, Xiao-Dong Liu, Jin-Xing Lou, Peng Chen, Bing Liu
JournalZhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 12 Issue 6 Pg. 855-7 (Dec 2004) ISSN: 1009-2137 [Print] China
PMID15631678 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Androgens
  • Hemoglobins
  • Immunosuppressive Agents
  • Cyclosporine
Topics
  • Adolescent
  • Adult
  • Aged
  • Androgens (therapeutic use)
  • Blood Cell Count
  • Cyclosporine (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Hemoglobins (analysis)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes (blood, drug therapy)
  • Treatment Outcome

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