[A case of advanced esophageal cancer responding remarkably to chemotherapy of TS-1 and weekly CDDP combined with radiotherapy].

Abstract

A 66-year-old patient, who had advanced esophageal cancer with lymph node metastasis, was treated by neoadjuvant chemo-radiotherapy, followed by curative surgery. Chemotherapy of TS-1 (80 mg/m2) was administered orally for 21 days, and weekly intravenous administration of CDDP (20 mg/m2) was done 3 times. Radiotherapy at 2 Gy/day was combined 15 times (total 30 Gy). The tumor responded well to the treatment, and the size was remarkably reduced. Chemoradiotherapy using TS-1 and weekly CDDP revealed their efficacy for esophageal cancer.

• Authors: Yoshihisa Sakaguchi, Akira Kabashima, Hideki Yamamoto, Rinshun Shimabukuro, Yasutomo Ojima, Shinji Yamamura, Takashi Nishizaki, Hideya Tashiro, Toshimitsu Matsusaka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 31 Issue 13 Pg. 2159-62 (Dec 2004) ISSN: 0385-0684 [Print] Japan
• PMID: 15628763 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Pyridines
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, radiotherapy, surgery)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Drug Combinations
• Esophageal Neoplasms (drug therapy, radiotherapy, surgery)
• Humans
• Male
• Neoadjuvant Therapy
• Oxonic Acid (administration & dosage)
• Preoperative Care
• Pyridines (administration & dosage)
• Tegafur (administration & dosage)