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Control of viral rebound through therapeutic immunization with DermaVir.

AbstractOBJECTIVE:
To reconstitute immune responses capable of eliminating infected cells and suppressing viral load during chronic retroviral infection.
DESIGN:
: A topical, DNA-based therapeutic immunization (DermaVir) was designed to express most of the regulatory and structural viral genes in dendritic cells.
METHODS:
DermaVir alone and in combination with antiretroviral drugs was tested in chronically SIV-infected macaques.
RESULTS:
DermaVir provided virological, immunological and clinical benefit for SIV-infected macaques during chronic infection and AIDS. In combination with antiretroviral drugs, DermaVir augmented SIV-specific T-cell responses and enhanced control of viral load rebound during treatment interruptions.
CONCLUSIONS:
The results indicate the feasibility of therapeutic immunization even in immune compromised hosts, and suggest that DermaVir can complement antiretroviral drugs to sustain suppression of HIV-1 replication.
AuthorsJulianna Lisziewicz, Jeffrey Trocio, Jianqing Xu, Lucia Whitman, Amy Ryder, Nyasha Bakare, Mark G Lewis, Wendeline Wagner, Angela Pistorio, Suresh Arya, Franco Lori
JournalAIDS (London, England) (AIDS) Vol. 19 Issue 1 Pg. 35-43 (Jan 03 2005) ISSN: 0269-9370 [Print] England
PMID15627031 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • AIDS Vaccines
  • DermaVir
  • RNA, Viral
Topics
  • AIDS Vaccines (adverse effects, therapeutic use)
  • Acquired Immunodeficiency Syndrome (drug therapy, immunology, virology)
  • Animals
  • Antiretroviral Therapy, Highly Active (methods)
  • CD4-Positive T-Lymphocytes (immunology)
  • Chronic Disease
  • Cohort Studies
  • Dendritic Cells (immunology)
  • Drug Therapy, Combination
  • Female
  • Immunization (methods)
  • Lymphocyte Count
  • Macaca
  • Male
  • RNA, Viral (analysis)
  • Simian Acquired Immunodeficiency Syndrome (drug therapy, immunology, virology)
  • Simian Immunodeficiency Virus (physiology)
  • Swine
  • Viral Load (methods)
  • Virus Replication (immunology)

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