Abstract | OBJECTIVE: To reconstitute immune responses capable of eliminating infected cells and suppressing viral load during chronic retroviral infection. DESIGN: : A topical, DNA-based therapeutic immunization ( DermaVir) was designed to express most of the regulatory and structural viral genes in dendritic cells. METHODS:
DermaVir alone and in combination with antiretroviral drugs was tested in chronically SIV-infected macaques. RESULTS:
DermaVir provided virological, immunological and clinical benefit for SIV-infected macaques during chronic infection and AIDS. In combination with antiretroviral drugs, DermaVir augmented SIV-specific T-cell responses and enhanced control of viral load rebound during treatment interruptions. CONCLUSIONS: The results indicate the feasibility of therapeutic immunization even in immune compromised hosts, and suggest that DermaVir can complement antiretroviral drugs to sustain suppression of HIV-1 replication.
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Authors | Julianna Lisziewicz, Jeffrey Trocio, Jianqing Xu, Lucia Whitman, Amy Ryder, Nyasha Bakare, Mark G Lewis, Wendeline Wagner, Angela Pistorio, Suresh Arya, Franco Lori |
Journal | AIDS (London, England)
(AIDS)
Vol. 19
Issue 1
Pg. 35-43
(Jan 03 2005)
ISSN: 0269-9370 [Print] England |
PMID | 15627031
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- AIDS Vaccines
- DermaVir
- RNA, Viral
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Topics |
- AIDS Vaccines
(adverse effects, therapeutic use)
- Acquired Immunodeficiency Syndrome
(drug therapy, immunology, virology)
- Animals
- Antiretroviral Therapy, Highly Active
(methods)
- CD4-Positive T-Lymphocytes
(immunology)
- Chronic Disease
- Cohort Studies
- Dendritic Cells
(immunology)
- Drug Therapy, Combination
- Female
- Immunization
(methods)
- Lymphocyte Count
- Macaca
- Male
- RNA, Viral
(analysis)
- Simian Acquired Immunodeficiency Syndrome
(drug therapy, immunology, virology)
- Simian Immunodeficiency Virus
(physiology)
- Swine
- Viral Load
(methods)
- Virus Replication
(immunology)
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