[Basophil activation tests in the diagnosis of drug reactions].

Abstract

Over the past 10 years a number of studies on basophil activation tests (BAT) have been published which focus on their use as diagnostic methods in clarifying IgE-mediated hypersensitivity reactions to various allergens including drugs. These BAT are based on flow cytometric quantification of allergen- induced CD63 or CD203 expression or measurement of sulfo leukotriene release by ELISA. In the diagnosis of penicillin allergy, the combined use of the CD63-BAT and specific IgE increases sensitivity. The role of BAT in the diagnosis of non-IgE-mediated reactions to non-steroidal anti- inflammatory drugs remains to be clarified. This article focuses on (1) the principles of BAT, (2) technical aspects, (3) clinical applications and (4) recommendations for further development.

• Authors: S M Erdmann, S Ventocilla, S Moll-Slodowy, I Sauer, H F Merk
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 56 Issue 1 Pg. 38-43 (Jan 2005) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Basophilenaktivierungstests in der Diagnostik von Arzneimittelreaktionen.
• PMID: 15625602 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Penicillins

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Basophil Degranulation Test (methods)
• Diagnosis, Differential
• Drug Eruptions (diagnosis)
• Humans
• Penicillins (adverse effects)
• Practice Guidelines as Topic
• Practice Patterns, Physicians'
• Risk Assessment (methods)
• Risk Factors
• Severity of Illness Index