Abstract |
We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 ( FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246 T>A and 21265 C>T) causing amino acid substitutions (Asp(198)Glu and Arg(205)Cys in exon 5), respectively. The Asp(198)Glu allele also presented together with known SNPs (20852 C>T in exon4, 20960_20962 CTT deletion, 21115 G>A in intron 4, and 21243_21244 TG deletion in exon 5) in the same allele of the FMO3 gene to form a novel haplotype. These sequences are as follows:1) SNP, 030609Fujieda019; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-TTCGGGCTG(TG/-)AT/AATTGCCACAGAA-3'.2) SNP, 030609Fujieda020; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5'-ACAGAACTCAGCC/TGCACAGCAGAAC-3'.
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Authors | Masaki Fujieda, Hiroshi Yamazaki, Masahiro Togashi, Tetsuya Saito, Tetsuya Kamataki |
Journal | Drug metabolism and pharmacokinetics
(Drug Metab Pharmacokinet)
Vol. 18
Issue 5
Pg. 333-5
( 2003)
ISSN: 1347-4367 [Print] England |
PMID | 15618753
(Publication Type: Journal Article)
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