Abstract | BACKGROUND: METHODS: Athymic nude mice (ovariectomized or intact) were implanted with tissue fragments of normal human endometrium. After establishment of lesions for 11-14 days, mice were treated with ERB-041 for 15-17 days. Upon euthanasia, the number of lesions, their size and location were noted. Five lesions were recovered for RNA analysis. RESULTS: Across six studies, ERB-041 caused complete lesion regression in 40-75% of the mice studied. The compound appeared to be equally effective in gonad-intact as in ovariectomized mice, and analysed recovered lesions expressed ERalpha but not ERbeta mRNA. CONCLUSIONS:
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Authors | Heather A Harris, Kaylon L Bruner-Tran, Xiaochun Zhang, Kevin G Osteen, C Richard Lyttle |
Journal | Human reproduction (Oxford, England)
(Hum Reprod)
Vol. 20
Issue 4
Pg. 936-41
(Apr 2005)
ISSN: 0268-1161 [Print] England |
PMID | 15618247
(Publication Type: Journal Article)
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Chemical References |
- ERB 041
- Estrogen Receptor beta
- Oxazoles
- RNA, Messenger
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Topics |
- Adolescent
- Adult
- Animals
- Biopsy
- Disease Models, Animal
- Endometriosis
(drug therapy, pathology)
- Endometrium
(drug effects, pathology)
- Estrogen Receptor beta
(agonists, genetics)
- Female
- Humans
- Mice
- Mice, Nude
- Middle Aged
- Organ Culture Techniques
- Ovariectomy
- Oxazoles
(chemistry, pharmacology)
- RNA, Messenger
(analysis)
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