[Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats].

Abstract

OBJECTIVE:

To investigate the protective effect of Ginsenoside Rg2 on Chemical myocardial ischemia.

METHOD:

The models of myocardial ischemia were built in rats with isoproterenol, sodium nitrite,pituitrin. Ginsenoside Rg2 (iv 2.5, 5.0, 10.0 mg x kg(-1)) were intravenously administered.

RESULT:

Ginsenoside Rg2 could improve the abnormal electrocardiogram (ECG), reduce the arca of myocardial ischemia and improve the abnormal zymologic value of myocardial.

CONCLUSION:

Ginsenoside Rg2 has inhibitory function on myocardialischemia.

• Authors: Jian-ming Tian, Hao Li, Jin-mei Ye, Wei-fang Guo, Lon-yun Li, Li-ping Wang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 28 Issue 12 Pg. 1191-2 (Dec 2003) ISSN: 1001-5302 [Print] China
• PMID: 15617510 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ginsenosides
• Pituitary Hormones, Posterior
• Malondialdehyde
• ginsenoside Rg2
• Superoxide Dismutase
• Creatine Kinase
• Isoproterenol
• Sodium Nitrite

Topics

• Animals
• Creatine Kinase (metabolism)
• Electrocardiography (drug effects)
• Female
• Ginsenosides (isolation & purification, pharmacology)
• Isoproterenol
• Male
• Malondialdehyde (metabolism)
• Myocardial Ischemia (chemically induced, pathology, physiopathology)
• Myocardium (pathology)
• Panax (chemistry)
• Pituitary Hormones, Posterior
• Plant Leaves (chemistry)
• Plants, Medicinal (chemistry)
• Rats
• Rats, Wistar
• Sodium Nitrite
• Superoxide Dismutase (metabolism)