[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].

Abstract

OBJECTIVE:

To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat.

METHOD:

Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia.

RESULT:

Ligustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI).

CONCLUSION:

The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.

• Authors: Yuan-jing Wang, An-hong Jiang, Qin-mao Wang, Mei Bai, Ke-long Ma
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 28 Issue 12 Pg. 1181-3 (Dec 2003) ISSN: 1001-5302 [Print] China
• PMID: 15617507 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endothelin-1
• Insulin
• Neuroprotective Agents
• Pyrazines
• Tumor Necrosis Factor-alpha
• Superoxide Dismutase
• tetramethylpyrazine

Topics

• Animals
• Brain Ischemia (blood, etiology)
• Endothelin-1 (blood)
• Female
• Infarction, Middle Cerebral Artery (complications)
• Insulin (blood)
• Insulin Resistance
• Male
• Neuroprotective Agents (pharmacology)
• Pyrazines (pharmacology)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (blood)
• Tumor Necrosis Factor-alpha (metabolism)