Abstract | BACKGROUND: METHODS: We compared the efficacy of long-acting furosemide (60 mg/day) and hydrochlorothiazide (25 mg/day) in a double-blind, randomized crossover trial in seven patients with severe renal failure and hypertension (seven men, 54+/-10 years old). The primary end-points were sodium and chloride fractional excretions after 1 month of each diuretic and then after their combination. During the trial, other treatments and the diet were controlled. RESULTS: A trend towards an increase in the fractional excretion of sodium and of chloride was observed with furosemide, but the difference did not reach the level of statistical significance (P = NS). Hydrochlorothiazide significantly increased fractional excretion of sodium and chloride from 3.7+/-0.9 to 5.5+/-0.3 and from 3.9+/-0.19 to 6.5+/-0.3, respectively (P<0.05). The combination of the two diuretics had no additional effect on the increase in sodium and chloride fractional excretion. Furosemide, hydrochlorothiazide and the combination of the two diuretics decreased mean arterial blood pressure by the same extent from 112 to 97, 99 and 97 mmHg, respectively (P<0.05). CONCLUSIONS:
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Authors | Bertrand Dussol, Julie Moussi-Frances, Sophie Morange, Claude Somma-Delpero, Olivier Mundler, Yvon Berland |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 20
Issue 2
Pg. 349-53
(Feb 2005)
ISSN: 0931-0509 [Print] England |
PMID | 15615808
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chlorides
- Diuretics
- Sodium Chloride Symporter Inhibitors
- Hydrochlorothiazide
- Furosemide
- Sodium
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Topics |
- Adult
- Aged
- Chlorides
(urine)
- Cross-Over Studies
- Diuretics
- Double-Blind Method
- Furosemide
(therapeutic use)
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(drug therapy, etiology)
- Kidney Failure, Chronic
(physiopathology)
- Male
- Middle Aged
- Sodium
(urine)
- Sodium Chloride Symporter Inhibitors
(therapeutic use)
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