Abstract | INTRODUCTION: METHODS AND RESULTS: The study consisted of 83 patients with isthmus-dependent atrial flutter: 52 were taking amiodarone at the time of RFA (group 1) and 31 were in a drug-free state (group 2). Entrainment mapping was performed from the cavotricuspid isthmus, and PPI minus TCL was determined. The two groups had similar baseline clinical characteristics. In all patients, RFA of the isthmus resulted in termination of tachycardia, confirming the isthmus-dependent nature of the flutter. TCL was significantly longer in group 1 than in group 2 (263 +/- 31 msec vs 238 +/- 27 msec, P < 0.0002). PPI minus TCL at the isthmus was significantly longer in group 1 than in group 2 (17 +/- 17 msec vs 8 +/- 4 msec, P < 0.01). More patients in group 1 had PPI-TCL>20 msec compared to group 2 (37% vs 10%, P = 0.01). CONCLUSION:
Amiodarone significantly alters the entrainment mapping response from the isthmus. In this setting, long return cycles exceeding the TCL by >20 msec do not exclude isthmus-dependent atrial flutter.
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Authors | Marjaneh Fatemi, Jacques Mansourati, Radu Rosu, Jean-Jacques Blanc |
Journal | Journal of cardiovascular electrophysiology
(J Cardiovasc Electrophysiol)
Vol. 15
Issue 12
Pg. 1409-15
(Dec 2004)
ISSN: 1045-3873 [Print] United States |
PMID | 15610288
(Publication Type: Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Amiodarone
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Topics |
- Aged
- Amiodarone
(therapeutic use)
- Anti-Arrhythmia Agents
(therapeutic use)
- Atrial Flutter
(drug therapy, physiopathology, surgery)
- Body Surface Potential Mapping
(methods)
- Cardiac Pacing, Artificial
(methods)
- Catheter Ablation
- Chi-Square Distribution
- Female
- Heart Conduction System
(physiopathology)
- Humans
- Logistic Models
- Male
- Prospective Studies
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