Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases.

Abstract

BACKGROUND:

Iron absorption is decreased in some individuals who have undergone bariatric surgery.

METHODS:

We evaluated measures of iron metabolism and therapeutic phlebotomy in 3 adults with hemochromatosis and HFE C282Y homozygosity who underwent bariatric surgery.

RESULTS:

1 male and 1 female had surgery before diagnosis of hemochromatosis (jejuno-ileal bypass and Roux-en-Y gastric bypass, respectively); neither had iron overload. Another man was treated with serial phlebotomy to induce iron depletion; later, he underwent Roux-en-Y gastric bypass. His maintenance phlebotomy requirement for hemochromatosis decreased substantially (on average approximately 1 unit each 71 days before surgery, and approximately 1 unit each 173 days after surgery). None of these patients developed iron deficiency, and none took supplemental iron.

CONCLUSIONS:

Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished.

• Authors: James C Barton
• Journal: Obesity surgery (Obes Surg) 2004 Nov-Dec Vol. 14 Issue 10 Pg. 1409-14 ISSN: 0960-8923 [Print] United States
• PMID: 15603661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HFE protein, human
• Hemochromatosis Protein
• Histocompatibility Antigens Class I
• Membrane Proteins

Topics

• Adult
• Aged
• Anastomosis, Roux-en-Y (adverse effects, methods)
• Female
• Gastric Bypass (adverse effects, methods)
• Gene Expression Regulation
• Hemochromatosis (etiology, genetics, physiopathology)
• Hemochromatosis Protein
• Histocompatibility Antigens Class I (genetics)
• Homozygote
• Humans
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Mutation, Missense
• Obesity, Morbid (diagnosis, surgery)
• Patient Satisfaction
• Postoperative Complications (diagnosis)
• Prognosis
• Risk Assessment
• Sampling Studies
• Treatment Outcome
• Weight Loss