Abstract | BACKGROUND: CASE REPORT: A young male patient with a cardiogenic shock was transferred to the authors' clinic for coronary angiography, after he had presented to another hospital with acute myocardial infarction. The angiography revealed a subtotal stenosis of the left anterior descending artery. Even after successful angioplasty and implantation of an intraaortic balloon pump as well as treatment with dobutamine, the patient was still unstable. It was therefore decided to use the Ca(2+) sensitizer and vasodilator levosimendan. Application of this new drug resulted in a quick and sustained improvement of hemodynamic parameters and allowed simultaneous treatment with beta-blockers. CONCLUSION:
Levosimendan can be used in addition to beta- and alpha-agonistic agents as well as in the presence of beta-blockers. If the promising results of smaller studies (LIDO, RUSSLAN) with respect to the mortality of the treated patients can be supported by a larger, already initiated study (SURVIVE), levosimendan would be a valuable alternative and/or addition to the conventional therapy of cardiogenic shock.
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Authors | Carsten Zobel, Hannes Reuter, Robert H G Schwinger |
Journal | Medizinische Klinik (Munich, Germany : 1983)
(Med Klin (Munich))
Vol. 99
Issue 12
Pg. 742-6
(Dec 15 2004)
ISSN: 0723-5003 [Print] Germany |
Vernacular Title | Einsatz des Ca2+-Sensitizers Levosimendan zur Behandlung eines Patienten im kardiogenen Schock. |
PMID | 15599685
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Cardiotonic Agents
- Hydrazones
- Pyridazines
- Receptors, Calcium-Sensing
- Vasodilator Agents
- Simendan
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Topics |
- Adult
- Angioplasty, Balloon, Coronary
- Cardiotonic Agents
(therapeutic use)
- Catheterization, Swan-Ganz
- Coronary Stenosis
(complications, surgery)
- Drug Therapy, Combination
- Hemodynamics
(drug effects)
- Humans
- Hydrazones
(therapeutic use)
- Intra-Aortic Balloon Pumping
- Male
- Myocardial Infarction
(complications, surgery)
- Pyridazines
(therapeutic use)
- Receptors, Calcium-Sensing
(antagonists & inhibitors)
- Shock, Cardiogenic
(drug therapy)
- Simendan
- Stents
- Vasodilator Agents
(therapeutic use)
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