Efficacy of ivermectin as an anthelmintic in leopard frogs.

Abstract

Ivermectin administered cutaneously at dosages of 2 mg/kg of body weight eliminated nematode infections in leopard frogs. Three clinical trials were conducted. In the first trial, 5 groups of 11 frogs were given ivermectin IM at dosages of 0, 0.2, 0.4, 2, or 20 mg/kg. All frogs given ivermectin IM at dosages of 2.0 mg/kg or greater died. In trial 2, 44 frogs, allotted to 5 groups, were given ivermectin cutaneously at 0, 0.2, 2, or 20 mg/kg. Cutaneously administered ivermectin was not toxic at dosages up to 20 mg/kg. In trial 3, nematode infections were eliminated in all 10 frogs treated cutaneously with ivermectin at 2.0 mg/kg.

• Authors: J Letcher, M Glade
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 200 Issue 4 Pg. 537-8 (Feb 15 1992) ISSN: 0003-1488 [Print] United States
• PMID: 1559897 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Ivermectin

Topics

• Administration, Cutaneous
• Animals
• Dose-Response Relationship, Drug
• Feces (parasitology)
• Injections, Intramuscular (veterinary)
• Ivermectin (administration & dosage, therapeutic use, toxicity)
• Nematode Infections (drug therapy, veterinary)
• Paralysis (chemically induced, veterinary)
• Rana pipiens (parasitology)
• Skin Absorption