HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Microflora cultivable from minocycline strips placed in persisting periodontal pockets.

AbstractOBJECTIVE:
The microflora that develops on minocycline strips, used as an adjunct in non-surgical periodontal therapy was studied.
DESIGN AND METHODS:
Minocycline (1.4 mg in polycaprolactone vehicle) and control strips were applied into all residual pockets (PD > or = 5mm, > or =2 pockets/subject) of patients with chronic periodontitis 1 month after a course of non-surgical periodontal therapy. Strips were inserted and retained for 3 days, changed to new strips for 3 more days and then removed. Strips were recovered from 14 (eight test, six control) of the 34 participants at day 0 (strip inserted, left for 30 s, removed), days 3 and 6, for (i) anaerobic culture, (ii) coliforms culture, using MacConkey agar, (iii) yeast culture, using Sabouraud's dextrose agar.
RESULTS:
The mean anaerobic cfu/strip (x10(5); control/test) were 2/6, 24/2, 11/2 at days 0, 3 and 6, respectively (P > 0.05). The corresponding mean proportion of Gram-negative rods and fusiforms were 27%/21%, 27%/15% and 55%/8%. The proportions of Gram-negative rods on test strips by day 6 were significantly reduced (P < 0.05). A significantly increased prevalence of Streptococcus mitis biovar 1 was found on spent test strips (control versus test; 0% versus 38%, Fisher exact test, P = 0.01). Coliform prevalence at days 0, 3 and 6 on control/test strips were 0/13%, 50%/38% and 50%/13%. Yeasts were occasionally isolated.
CONCLUSIONS:
The findings indicated that the minocycline strips but not the control strip supported a microbial colonisation compatible with periodontal health by day 6.
AuthorsW Keung Leung, Lijian Jin, Joyce Y Y Yau, Qiang Sun, Esmonde F Corbet
JournalArchives of oral biology (Arch Oral Biol) Vol. 50 Issue 1 Pg. 39-48 (Jan 2005) ISSN: 0003-9969 [Print] England
PMID15598416 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Pharmaceutical Vehicles
  • Minocycline
Topics
  • Administration, Oral
  • Anti-Bacterial Agents (administration & dosage)
  • Bacteria, Aerobic (isolation & purification)
  • Bacteria, Anaerobic (isolation & purification)
  • Chronic Disease
  • Colony Count, Microbial
  • Enterobacteriaceae (isolation & purification)
  • Female
  • Gram-Negative Facultatively Anaerobic Rods (isolation & purification)
  • Humans
  • Male
  • Middle Aged
  • Minocycline (administration & dosage)
  • Periodontal Pocket (drug therapy, microbiology)
  • Periodontium (microbiology)
  • Pharmaceutical Vehicles
  • Streptococcus mitis (isolation & purification)
  • Yeasts (isolation & purification)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: