HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Dendritic cells and macrophages are productively infected by poliovirus.

Abstract
Expression of the poliovirus receptor (PVR) on cells is a major host determinant of infection by poliovirus. Previously, the only immune cell type known to express PVR was the blood-derived monocyte, which is susceptible to infection at very low frequency. We demonstrate that professional antigen-presenting cells-macrophages and dendritic cells, generated upon differentiation of monocytes-retain expression of PVR and are highly susceptible to infection by type 1 Mahoney strain of poliovirus. Maximal cell-associated titers of virus are obtained within 6 to 8 h postinfection, and cell death and lysis occurs within 24 h postinfection. Similar kinetics are observed in cells infected with the Sabin 1 vaccine strain. Although protein synthesis and receptor-mediated endocytosis are inhibited upon poliovirus infection of these critical antigen-presenting cells, we demonstrate for the first time that functional presentation of antigen occurs in these infected cells via the HLA class II pathway.
AuthorsRahnuma Wahid, Martin J Cannon, Marie Chow
JournalJournal of virology (J Virol) Vol. 79 Issue 1 Pg. 401-9 (Jan 2005) ISSN: 0022-538X [Print] United States
PMID15596833 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Histocompatibility Antigens Class II
  • Poliovirus Vaccine, Oral
  • Proteins
Topics
  • Antigen Presentation
  • Apoptosis
  • CD8-Positive T-Lymphocytes (immunology)
  • Cells, Cultured
  • Dendritic Cells (virology)
  • Endocytosis
  • Histocompatibility Antigens Class II (metabolism)
  • Humans
  • Macrophages (virology)
  • Monocytes (virology)
  • Poliovirus (pathogenicity)
  • Poliovirus Vaccine, Oral
  • Proteins (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: