Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa.

Abstract

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.

• Authors: Gao Li, Chang-Seob Seo, Kyeung-Seon Lee, Hyo-Jin Kim, Hyun-Wook Chang, Jun-Sub Jung, Dong-Keun Song, Jong-Keun Son
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 27 Issue 11 Pg. 1123-6 (Nov 2004) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 15595414 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Plant Extracts
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Analysis of Variance
• Animals
• Male
• Mice
• Mice, Inbred ICR
• Paeonia (chemistry)
• Plant Extracts (chemistry, pharmacology)
• Plant Roots (chemistry)
• Sepsis (blood, mortality, prevention & control)
• Survival Rate
• Time Factors