Splitting hairs--discovery of a new DNA repair and transcription factor for the human disease trichothiodystrophy.

Abstract

The gene responsible for the TTD-A group of the DNA repair deficient disease trichothiodystrophy has been identified as a small, 8 kDa, component of the transcription factor TFIIH which contributes to the stability and concentration of TFIIH in vivo.

• Authors: James E Cleaver
• Journal: DNA repair (DNA Repair (Amst)) Vol. 4 Issue 2 Pg. 285-7 (Feb 03 2005) ISSN: 1568-7864 [Print] Netherlands
• PMID: 15590337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Transcription Factors, TFII
• Transcription Factor TFIIH

Topics

• DNA Repair
• Hair Diseases (genetics)
• Humans
• Transcription Factor TFIIH
• Transcription Factors, TFII (physiology)
• Transcription, Genetic