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Screening of bioactive metabolites for pancreatic regeneration chemotherapy.

Abstract
Plants and microorganisms are the treasury of bioactive metabolites including useful chemical ligands. Chemical ligands that induce beta-cell differentiation may be useful as new therapeutic agents for both type-1 and type-2 diabetes mellitus. We isolated conophylline from the leaves of Ervatamia microphylla as an agent that induce insulin production in rat pancreatic acinar carcinoma cells.
AuthorsHiroshi Takatsuna, Kazuo Umezawa
JournalBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 58 Issue 10 Pg. 610-3 (Dec 2004) ISSN: 0753-3322 [Print] France
PMID15589071 (Publication Type: Journal Article, Review)
Topics
  • Animals
  • Drug Evaluation, Preclinical (methods)
  • Humans
  • Pancreas (cytology, drug effects, physiology)
  • Regeneration (drug effects, physiology)

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