Abstract |
The objectives of this study were to evaluate adrenal function after otic glucocorticoid [ Tresaderm ( dexamethasone) and Otomax ( betamethasone)] therapy in small-breed dogs without evidence of otitis and to evaluate the length of time needed for resolution of adrenal suppression after discontinuation of treatment. Fourteen clinically healthy, privately owned, small-breed dogs with normal ears and normal adrenocorticotropin ( ACTH) stimulation tests were assigned to one of two treatment groups, receiving one of the medications at the manufacturer's recommended dosage twice daily for 2 weeks. All of the dogs in the betamethasone treatment group had normal ACTH stimulation tests after 2 weeks of treatment. In contrast, 5/7 (71.43%) in the dexamethasone group, had suppressed adrenocortical responses to exogenous ACTH. Three of these five dogs (42%) returned to normal values 1 week after ceasing the medication and two (28.57%) returned to normal values 2 weeks after ceasing the medication. In conclusion, it appears that adrenal function can be suppressed for up to 2 weeks in dogs receiving otic dexamethasone. A follow-up study repeating this work in dogs with inflamed ears is needed before further clinical recommendations can be made.
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Authors | R Ghubash, R Marsella, G Kunkle |
Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 15
Issue 6
Pg. 363-8
(Dec 2004)
ISSN: 0959-4493 [Print] England |
PMID | 15585011
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Dexamethasone
- Betamethasone
- Hydrocortisone
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Topics |
- Administration, Topical
- Adrenal Insufficiency
(blood, chemically induced, veterinary)
- Animals
- Betamethasone
(administration & dosage, adverse effects)
- Body Size
- Dexamethasone
(administration & dosage, adverse effects)
- Dog Diseases
(blood, chemically induced)
- Dogs
- Ear
- Female
- Glucocorticoids
(administration & dosage, adverse effects)
- Hydrocortisone
(blood)
- Male
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