Abstract |
Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous vegetables has anticancer activities which is in line with some of the epidemiological evidence that suggests a beneficial effect of consumption of cruciferous vegetables on cancer incidence and progression. The precise target of indole-3-carbinol has not been determined. We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu. This cell line derived from a tumor in Copenhagen rats is androgen independent and metastasizes to the lung and lymph nodes. Tumors were induced in Copenhagen rats by injecting MAT-LyLu subcutaneously and the animals treated with I3C that was administered either intraperitoneally or intravenously, in order to achieve maximal systemic exposure. This was a departure from the traditional chemopreventive route of indole-3-carbinol where the compound was incorporated in the diet. Our results indicate that I3C inhibited the incidence, growth and metastases of MAT-LyLu cells and both i.p. and i.v. injections of I3C were equally effective. Statistical analysis (Kaplan-Meier curves) clearly indicates a tumor-free and overall survival benefit as a result of treatment with I3C. These studies show for the first time that I3C in an injectible form has anti- prostate cancer activity.
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Authors | V P S Garikapaty, B T Ashok, Y G Chen, A Mittelman, M Iatropoulos, R K Tiwari |
Journal | Oncology reports
(Oncol Rep)
Vol. 13
Issue 1
Pg. 89-93
(Jan 2005)
ISSN: 1021-335X [Print] Greece |
PMID | 15583807
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Anticarcinogenic Agents
- Indoles
- indole-3-carbinol
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Topics |
- Animals
- Anticarcinogenic Agents
(therapeutic use)
- Disease Models, Animal
- Indoles
(therapeutic use)
- Lung Neoplasms
(prevention & control, secondary)
- Male
- Neoplasm Transplantation
- Prostatic Neoplasms
(pathology, prevention & control)
- Rats
- Rats, Inbred Strains
- Tumor Cells, Cultured
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