Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology.

Abstract

Tremorine-induced tremors model is used to evaluate antiparkinsonian drugs because rest tremor is a sign that distinguishes Parkinson's disease (PD) from other diseases. The effects of crude ethanolic extract (CEE) and total acetate fraction (TAF) of Plumbago scandens were investigated at several doses. These extracts at doses of 125 and 250 mg/kg i.p. failed to reduce tremors in tremorine-treated mice. TAF showed significant effects only at a dose of 500 mg/kg. Both CEE and TAF at doses of 1000 and 2000 mg/kg i.p. suppressed the tremors in a dose-dependent fashion for 60 min. Biperiden, an anticholinergic drug, was used as standard at a dose of 3 mg/kg i.p. This study suggests that P. scandens is a plant with possible therapeutic value for PD.

• Authors: L C S L Morais, L J Quintans-Júnior, C I F Franco, J R G S Almeida, R N Almeida
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 79 Issue 4 Pg. 745-9 (Dec 2004) ISSN: 0091-3057 [Print] United States
• PMID: 15582683 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiparkinson Agents
• Plant Extracts
• Tremorine

Topics

• Animals
• Antiparkinson Agents (isolation & purification, therapeutic use)
• Male
• Mice
• Plant Extracts (isolation & purification, therapeutic use)
• Plant Structures
• Plumbaginaceae
• Tremor (chemically induced, drug therapy)
• Tremorine (toxicity)