A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.

Abstract

Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM.

• Authors: Kyung Noo Kim, Jiyong Lee, Dong Hoon Kim, Jong-Shin Yoo, Ho Jeong Kwon
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 15 Issue 1 Pg. 77-9 (Jan 03 2005) ISSN: 0960-894X [Print] England
• PMID: 15582414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 7-(3-bromo-phenoxy)-thymidine
• Thymidine

Topics

• Cell Division (drug effects)
• HeLa Cells
• Humans
• Thymidine (analogs & derivatives, chemical synthesis, chemistry, pharmacology)