[Non-histaminic angiodema management: diagnostic and therapeutic interest of tranexamic acid].

Abstract

INTRODUCTION:

The diagnosis of chronic angioedema (localised and reversible oedema) is sometimes very difficult when there is no efficiency of anti-histaminics and corticosteroids. In these cases, bradykinin angioedema must be mentioned. Tranexamic acid is efficient and must be proposed.

STUDY:

We reported seven patients who have a non-histaminergic angioedema since an average of 8 years. Corticosteroids and histamine-1 blockers were not efficient. Daily tranexamic acid treatment (1 g x 3 per day) controlled the disease. Three patients had no more attack. The C1Inh antigen and function levels were normal. No secondary effect was described and all patients are still being treated (average of 20 months).

CONCLUSION:

When a non-histaminergic angioedema is suspected, tranexamic acid must be proposed as attack's treatment and as prophylactic treatment.

• Authors: L Bouillet, D Ponard, C Drouet, C Massot
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 25 Issue 12 Pg. 924-6 (Dec 2004) ISSN: 0248-8663 [Print] France
• Vernacular Title: Intérêt diagnostic et thérapeutique de l'acide tranexamique dans les angio-oedèmes non-histaminiques.
• PMID: 15582173 (Publication Type: English Abstract, Journal Article)

Chemical References

• Tranexamic Acid

Topics

• Adolescent
• Adult
• Angioedema (diagnosis, drug therapy)
• Female
• Humans
• Male
• Tranexamic Acid (therapeutic use)