Abstract |
Using intravital microscopy, we compared the responses to serotonin [ 5-hydroxytryptamine (5-HT)] and to a specific 5-HT2 agonist [1-(2,5-dimethoxy-4-bromo-phenyl)-2-aminopropane (DOB)] by normal arterioles and by the host-modified arterioles feeding a Meth A tumor implanted into the flank of female BALB/c mice. Topical and intravenous administration of 5-HT (10(-6) to 10(-4) M and 0.01-10 micrograms) or DOB (5 x 10(-7) to 5 x 10(-5) M and 0.01-10 micrograms) induced arteriolar constriction, which was far more pronounced for the arterioles feeding the tumor. This larger degree of vasoconstriction in tumor-feeding vs. normal arterioles was not found with norepinephrine. We also compared tumor growth and the mouse life span in three groups of mice, which were given 1 mg of serotonin or 0.74 mg DOB or saline solution. 5-HT or DOB both reduced tumor growth drastically compared with the controls (P less than 0.001), and survival rates were significantly higher in the 5-HT or DOB-treated groups (P less than 0.001). We conclude that 5-HT2-serotoninergic agonists are of particular pharmacological interest, since their vasoconstrictive action on the microvasculature feeding the tumors is much greater than in normal tissue and may interfere with tumor growth.
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Authors | O Stücker, E Vicaut, B Teisseire |
Journal | The American journal of physiology
(Am J Physiol)
Vol. 262
Issue 3 Pt 2
Pg. H704-9
(Mar 1992)
ISSN: 0002-9513 [Print] United States |
PMID | 1558179
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Serotonin
- 2,5-Dimethoxy-4-Methylamphetamine
- 2,5-dimethoxy-4-bromoamphetamine
- Serotonin
- Norepinephrine
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Topics |
- 2,5-Dimethoxy-4-Methylamphetamine
(analogs & derivatives, pharmacology)
- Analysis of Variance
- Animals
- Arterioles
(drug effects, physiology, physiopathology)
- Cell Division
(drug effects)
- Dose-Response Relationship, Drug
- Fibrosarcoma
(blood supply, pathology)
- Mice
- Mice, Inbred BALB C
- Muscle, Smooth, Vascular
(drug effects, physiology, physiopathology)
- Norepinephrine
(pharmacology)
- Receptors, Serotonin
(drug effects, physiology)
- Reference Values
- Sarcoma, Experimental
(blood supply, pathology)
- Serotonin
(pharmacology)
- Skin
(blood supply)
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