Increased intraocular pressure and corneal endothelial cell loss following phacoemulsification surgery.

Abstract

BACKGROUND AND OBJECTIVE:

To compare the influence of low-molecular-weight viscoelastics on postoperative intraocular pressure (IOP) and corneal endothelial cell loss after phacoemulsification

PATIENTS AND METHODS:

Sixty-nine eyes undergoing phacoemulsification surgery were randomized to have either Opegan (Santen Pharmaceuticals, Osaka, Japan) alone or the soft-shell technique using Viscoat (Alcon Surgical, Fort Worth, TX) during phacoemulsification. The IOP was measured preoperatively and at 5 and 24 hours postoperatively. Intraoperative factors and corneal endothelial cell loss were also examined.

RESULTS:

Mean IOP was increased at 5 hours after surgery but returned to preoperative levels at 24 hours in the Opegan group, whereas it remained higher at 24 hours than at preoperative levels in the soft-shell group. When comparing groups, IOP at 5 and 24 hours postoperatively in the Opegan group was significantly less than that in the soft-shell group. Corneal endothelial cell loss was approximately the same in the two groups.

CONCLUSION:

The increase in IOP following phacoemulsification surgery with the use of Opegan was less than that with the soft-shell technique using Viscoat, although endothelial injury was almost the same.

• Authors: Ryuzi Yachimori, Toshie Matsuura, Ken Hayashi, Hideyuki Hayashi
• Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye (Ophthalmic Surg Lasers Imaging) 2004 Nov-Dec Vol. 35 Issue 6 Pg. 453-9 ISSN: 1542-8877 [Print] United States
• PMID: 15580967 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• chondroitin sulfate, sodium hyaluronate drug combination
• Hyaluronic Acid
• Chondroitin
• Chondroitin Sulfates

Topics

• Aged
• Aged, 80 and over
• Cell Count
• Chondroitin (therapeutic use)
• Chondroitin Sulfates
• Drug Combinations
• Endothelium, Corneal (pathology)
• Female
• Humans
• Hyaluronic Acid (therapeutic use)
• Intraocular Pressure
• Male
• Middle Aged
• Molecular Weight
• Ocular Hypertension (etiology)
• Phacoemulsification (adverse effects)
• Postoperative Complications