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A novel use for drotrecogin alfa (activated): successful treatment of septic shock associated with coccidioidomycosis.

Abstract
We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (activated) may be a valuable adjunct for treating septic shock due to endemic mycoses.
AuthorsNancy F Crum, Harold L Groff, John S Parrish, William Ring
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 39 Issue 11 Pg. e122-3 (Dec 01 2004) ISSN: 1537-6591 [Electronic] United States
PMID15578351 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Infective Agents
  • Protein C
  • Recombinant Proteins
  • drotrecogin alfa activated
Topics
  • Aged
  • Anti-Infective Agents (therapeutic use)
  • Coccidioidomycosis (complications, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Protein C (therapeutic use)
  • Recombinant Proteins (therapeutic use)
  • Remission Induction
  • Shock, Septic (drug therapy, etiology)

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