Abstract | CASE REPORT: A 70-year-old woman, with a history of diabetes and persistent corneal ulceration, developed a severe keratitis caused by Candida albicans. It evolved rapidly to corneal perforation in spite of treatment with topical amphotericin B and oral itraconazole. An amniotic membrane transplant was performed as an emergency, associated with systemic administration of voriconazole. The infection was solved successfully, although the patient needed a penetrating keratoplasty to restore the corneal transparency. DISCUSSION: Fungal keratitis caused by Candida albicans usually follows an aggressive course and may simulate a bacterial aetiology. Voriconazole is a new antifungal drug that appears to be very effective in the management of ocular infections caused by many filamentous and levaduriform fungi.
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Authors | J M Granados, N Puerto, M J Carrilero |
Journal | Archivos de la Sociedad Espanola de Oftalmologia
(Arch Soc Esp Oftalmol)
Vol. 79
Issue 11
Pg. 565-8
(Nov 2004)
ISSN: 0365-6691 [Print] Spain |
Vernacular Title | Eficacia del voriconazol en queratitis fúngica por cándida albicans. |
PMID | 15578288
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antifungal Agents
- Pyrimidines
- Triazoles
- Voriconazole
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Topics |
- Aged
- Antifungal Agents
(therapeutic use)
- Candidiasis
(drug therapy)
- Female
- Humans
- Keratitis
(drug therapy, microbiology)
- Pyrimidines
(therapeutic use)
- Triazoles
(therapeutic use)
- Voriconazole
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