[Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application].

Abstract

After single intradiscal injection of C-ABC in rabbit inter-vertebral discs, water content in the matrix of nucleus pulposus diminished clearly. After similar injection of C-ABC in sheep discs, disc inner pressure was diminished. After single intradiscal injection of C-ABC in dog inter-vertebral discs suffering disc herniation, the syndromes coming from the herniation diminished or disappeared. Based on these observations C-ABC is expected to be a chemonucleolytic agent and a human clinical trial is now in progress.

• Authors: Toyomi Takahashi
• Journal: Clinical calcium (Clin Calcium) Vol. 14 Issue 7 Pg. 85-9 (Jul 2004) ISSN: 0917-5857 [Print] Japan
• PMID: 15577082 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Chondroitin ABC Lyase

Topics

• Animals
• Chondroitin ABC Lyase (administration & dosage)
• Dogs
• Humans
• Injections, Intralesional
• Intervertebral Disc Chemolysis
• Intervertebral Disc Displacement (drug therapy)
• Lumbar Vertebrae
• Rabbits
• Sheep