Anti-angiogenic activity of convallamaroside, the steroidal saponin isolated from the rhizomes and roots of Convallaria majalis L.

Abstract

Angiogenesis plays a pivotal role in tumor growth and represents a key target for chemopreventive intervention. Despite the large number of existing angiogenesis inhibitors, there is still a great demand for new anti-angiogenic compounds. The objective of this study is to investigate the effect of administration of convallamaroside, a steroidal saponin isolated from the lily of the valley (Convallaria majalis L.) to mice on tumor angiogenesis reaction induced by tumor cells. Angiogenic activity was evaluated by mice intradermal test. Convallamaroside showed a significant inhibitory effect on the number of new vessels induced in mice by human kidney tumor cells (p < 0.001). Similarly, administration of convallamaroside to mice decreased the number of new vessels induced by sarcoma mice cells (p < 0.001).

• Authors: Jadwiga Nartowska, Ewa Sommer, Krzysztof Pastewka, Sylwester Sommer, Ewa Skopińska-Rózewska
• Journal: Acta poloniae pharmaceutica (Acta Pol Pharm) 2004 Jul-Aug Vol. 61 Issue 4 Pg. 279-82 ISSN: 0001-6837 [Print] Poland
• PMID: 15575594 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Saponins
• Steroids
• convallamaroside

Topics

• Angiogenesis Inhibitors (chemistry, isolation & purification, pharmacology)
• Animals
• Convallaria (chemistry)
• Dose-Response Relationship, Drug
• Mice
• Mice, Inbred BALB C
• Rhizome (chemistry)
• Saponins (chemistry, isolation & purification, pharmacology)
• Steroids (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured