[Association of polymorphic marker A1/A2 of gene ITGB3 with coronary artery disease and myocardial infarction].

Abstract

The distributions of the alleles and genotypes of polymorphic marker A1/A2 of gene ITGB3 encoding the beta3 subunit of integrin alphaIIbbeta3 in groups of patients with coronary artery disease (CAD), including those who have had myocardial infarction (MI), and in the control group have been compared. Analysis using Fisher's test has not revealed significant differences between these groups with respect to the distributions of the alleles and genotypes of polymorphic marker A1/A2 of gene ITGB3. This indicates that this polymorphic marker is not associated with either CAD or MI in the Moscow population.

• Authors: D A Chudakova, L O Minushkina, D A Zateĭshchikov, V V Nosikov
• Journal: Genetika (Genetika) Vol. 40 Issue 10 Pg. 1402-5 (Oct 2004) ISSN: 0016-6758 [Print] Russia (Federation)
• Vernacular Title: Assotsiatsiia polimorfnogo markera A1/A2 gena ITGB3 s ishemicheskoĭ bolezn'iu serdtsa i infarktom miokarda.
• PMID: 15575508 (Publication Type: English Abstract, Journal Article)

Chemical References

• Genetic Markers
• ITGB3 protein, human
• Integrin beta3

Topics

• Case-Control Studies
• Coronary Disease (genetics)
• Female
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (genetics)
• Humans
• Integrin beta3 (genetics)
• Male
• Moscow
• Myocardial Infarction (genetics)